VIP, human, bovine, porcine, rat
Product Code: CS1874

His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2

C₁₄₇H₂₃₈N₄₄O₄₂S
MW: 3325.77
CAS: [40077-57-4]
Longterm storage temperature: -20 C

VIP, a 28-amino acid peptide belonging to the secretin-glucagon-CRF family, is widely distributed in the central and peripheral nervous systems. Acting both as a neurotransmitter and as a hormone, VIP is involved in a wide variety of biological activities, including vaso- and bronchodilation, smooth muscle relaxation, and stimulation of secretion. An injectable formulation of this peptide in combination with the adrenergic drug phentolamine is expected to provide a new and effective alternative for erectile dysfunction patients.

Literature:
I.Gozes and D.E.Brenneman, Mol. Neurobiol., 3, 201 (1989)
J.Fahrenkrug, Pharmac. Ther., 41, 515 (1989)
E.J.Goetzl et al., Ann. N.Y. Acad. Sci., 594, 34 (1990)
G.D.Wenger and M.S.O'Dorisio, Ann. N.Y. Acad. Sci., 594, 104 (1990)
S.I.Said, Am. Rev. Respir. Dis., 143, S22 (1991)
G.B.Keijzers, Curr. Opin. Invest. Drugs, 2, 545 (2001)
V.Petkov et al., J. Clin. Invest., 111, 1339 (2003)
V.Sethi et al., Meth. Enzymol., 391, 377 (2005)
W.I.Said et al., Peptides, 28, 1620 (2007)