Thr-Ala-Pro-Arg-Atrial Natriuretic Factor (1-28), human, bovine, porcine
Synonym: Urodilatin
Product Code: CS9178

H-Thr-Ala-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH
(Disulfide bond 11-27) (Trifluoroacetate salt)

C₁₄₅H₂₃₄N₅₂O₄₄S₃
MW:3505.98
CAS: [115966-23-9]
Longterm storage temperature: -20 C

Urodilatin, a 32 amino acid peptide, has originally been isolated from human urine. It belongs to the family of natriuretic-vasorelaxant peptides earlier found in heart atria. Cedidi et al. showed that urodilatin infusion may represent a concept for the treatment of therapy-resistant acute renal failure after liver transplantation.

Literature:
M.Gagelmann et al., FEBS Lett., 233, 249 (1988)
V.di Marzo et al., Trends Pharmacol. Sci., 10, 91 (1989)
A.J.Kenny et al., Biochem. J., 291, 83 (1993)
T.Flüge et al., Eur. J. Pharmacol., 271, 395 (1994)
C.Cedidi et al., Eur. J. Clin. Invest., 24, 632 (1994)