Stichodactyla helianthus Neurotoxin (ShK)
Product Code: CS2286

Arg-Ser-Cys-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys-Thr-Ala-Phe-Gln-Cys-Lys-His-Ser-Met-Lys-Tyr-Arg-Leu-Ser-Phe-Cys-Arg-Lys-Thr-Cys-Gly-Thr-Cys
(Disulfide bonds 3-35, 12-28, 17-32)

C₁₆₉H₂₇₄N₅₄O₄₈S₇
MW: 4054.82
CAS: [172450-46-3]
Longterm storage temperature: -20 C

ShK-toxin, originally isolated from the sea anemone Stichodactyla helianthus, has been found to inhibit the specific binding of dendrotoxin I to rat brain membranes. Due to its unique structure (it contains three intramolecular disulfide bridges) and high affinity for some potassium channels, ShK-toxin may become a useful molecular probe for investigating potassium channels.

Literature:
J.Pohl et al., Lett. Pept. Sci., 1, 291 (1994)
W.R.Kem et al., Lett. Pept. Sci., 3, 69 (1996)
M.W.Pennington et al., Peptides: Chemistry, Structure and Biology, p. 192, P.T.P.Kaumaya and R.S.Hodges, eds., Mayflower Scientific Ltd., (1996)
M.W.Pennington et al., Biochem. Biophys. Res. Commun., 219, 696 (1996)
M.W.Pennington et al., Biochemistry, 35, 16407 (1996)
J.E.Tudor et al., Nat. Struct. Biol., 3, 317 (1996)
M.W.Pennington et al., A Guidebook to Protein Toxins and their Use in Cell Biology, p. 159, C.Montecucco and R.Rappuoli, eds., Oxford University Press, (1997)
J.E.Tudor et al., Eur. J. Biochem., 251, 133 (1998)
M.D.Lanigan et al., Biochemistry, 40, 15528 (2001)
K.G.Chandy et al., Trends Pharmacol. Sci., 25, 280 (2004)