Sarafotoxin C
Product Code: CS9062

Cys-Thr-Cys-Asn-Asp-Met-Thr-Asp-Glu-Glu-Cys-Leu-Asn-Phe-Cys-His-Gln-Asp-Val-Ile-Trp (Disulfide bonds 1-15, 3-11)

C₁₀₃H₁₄₇N₂₇O₃₇S₅
MW: 2515.77
CAS: [121695-87-2]
Longterm storage temperature: -20 C

Highly selective ET-B receptor antagonist. This selective ET receptor subtype B agonist is a vasoconstrictor peptide. In experiments on renal vasoconstrictor actions, sarafotoxin 6c appears to be potent at the renal resistance vasculature and is powerfully modulated by NO. It plays a role in cytosolic Ca2+ concentration ([Ca2+]i) balance.The differences between central helix of the endothelin and sarafotoxin isopeptides might be important in binding of these ligands by the G protein-coupled endothelin receptors.

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Watanabe, C. et al. Br. J. Pharmacol. 108, 30 (1993)
Marshall, JL. and JJ. Edward, Br. J. Pharmacol. 128, 809 (1999)