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Peptide YY (3-36), human

Peptide YY (3-36), human
Product Code: CS3114

Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-NH2


C180H279N53O54
MW: 4049.60
CAS: [123583-37-9]
Longterm storage temperature: -20 C


PYY (3-36), a Y2 receptor agonist, is released from the body's gastrointestinal tract in proportion to caloric intake. It has been shown that peripheral injection of PYY (3-36) in rats inhibited food intake and reduced weight gain. In addition, infusion of PYY (3-36) in humans significantly decreased appetite and reduced food intake by 33% over 24h, which suggests that PYY (3-36) has a role in 'longer term' regulation of food intake. Thus, the PYY (3-36) may represent a lead compound for the development of drugs for the treatment of obesity.


Literature:
G.A.Eberlein et al., Peptides, 10, 797 (1989)
D.Grandt et al., Regul. Peptides, 40, 161 (1992)
R.L.Batterham et al., Nature, 418, 650 (2002)
R.L.Batterham et al., N. Engl. J. Med., 349, 941 (2003)
C.Acuna-Goycolea and A.N.van den Pol, J. Neurosci., 25, 10510 (2005)
I.G.Halatchev and R.D.Cone, Cell Metab., 1, 159 (2005)
Y.Shechter et al., FEBS Lett., 579, 2439 (2005)
G.H.Ballantyne, Obes. Surg., 16, 651 (2006)

UnitPrice per Unit
0.5 mg $100
1 mg
$160