pTH (1-31) amide, human
Product Code: CS9206

H-Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-NH2

C₁₆₂H₂₇₀N₅₀O₄₆S₂
MW:3718.37
CAS: [173833-08-4]
Longterm storage temperature: -20 C

pTH (1-31) amide appears so far to be the smallest of the potently osteogenic pTH fragments. The osteogenic activity of this pTH fragment seems to be related to its ability to activate adenylyl cyclase. Unlike pTH, this fragment does not activate phospholipase C and should therefore have fewer side-effects and find application in the osteoporosis treatment.

Literature:
J.F.Whitfield and P.Morley, Trends Pharmacol. Sci., 16, 382 (1995)