Preptin, human
Product Code: CS9157

H-Asp-Val-Ser-Thr-Pro-Pro-Thr-Val-Leu-Pro-Asp-Asn-Phe-Pro-Arg-Tyr-Pro-Val-Gly-Lys-Phe-Phe-Gln-Tyr-Asp-Thr-Trp-Lys-Gln-Ser-Thr-Gln-Arg-Leu-OH
(Trifluoroacetate salt)

C₁₈₇H₂₇₅N₄₇O₅₃
MW:4029.53
CAS: [315197-69-4]
Longterm storage temperature: -20 C

Preptin is a 34-amino acid peptide hormone, corresponding to Asp69-Leu102 of the proinsulin-like growth factor II E-peptide. It is co-secreted with insulin and amylin from the pancreatic β-cells and is a physiological amplifier of glucose-mediated insulin secretion. It is also anabolic to bone tissue and may contribute to the preservation of bone mass observed in hyperinsulinemic states such as obesity.

Literature:
C.M.Buchanan et al., Biochem. J., 360, 431 (2001)
J.Cornish et al., Am. J. Physiol. Endocrinol. Metab., 292, E117 (2007)