Oxyntomodulin, bovine, dog, porcine
Synonym: Glucagon-37, bovine, dog, porcine
Product Code: CS4347

His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-Lys-Arg-Asn-Lys-Asn-Asn-Ile-Ala

C₁₉₂H₂₉₅N₅₉O₆₀S
MW: 4421.83
CAS: [74870-06-7]
Longterm storage temperature: -20 C

Glucagon-37 is released from the gut postprandially, in proportion to energy intake. Circulating levels of glucagon-37 are elevated in several conditions associated with anorexia. Central injection of glucagon-37 reduces food intake and weight gain in rodents, suggesting that glucagon-37 signals food ingestion to hypothalamic appetite-regulating circuits.

Literature:
D.Bataille et al., Peptides, 2 (suppl. 2), 41 (1981)
D.Bataille et al., Ann. N.Y. Acad. Sci., 527, 168 (1988)
M.A.Cohen et al., J. Clin. Endocrinol. Metab., 88, 4696 (2003)