Noxiustoxin
Product Code: CS9054

Thr-Ile-Ile-Asn-Val-Lys-Cys-Thr-Ser-Pro-Lys-Gln-Cys-Ser-Lys-Pro-Cys-Lys-Glu-Leu-Tyr-Gly-Ser-Ser-Ala-Gly-Ala-Lys-Cys-Met-Asn-Gly-Lys-Cys-Lys-Cys-Tyr-Asn-Asn-NH2 (Disulfide bonds 7-29, 13-34, 17-36)

C₁₇₄H₂₈₆N₅₂O₅₄S₇
MW: 4194.89
CAS:
Longterm storage temperature: -20 C

Noxiustoxin, which has been purified from the venom of the Mexican scorpion Centruroides noxius, blocks specifically Ca2+ activated K+ channels of small conductance obtained from cultured bovine aortic endothelial cells with an IC50 of 0.5 µM. Charybdotoxin and iberiotoxin belong to the same family of peptides targeting K+ channels and share about 50% sequence homology with noxiustoxin.

Literature:
R.F.Nutt et al., Peptides 1992, Proceedings of the 22nd European Peptide Symposium, Interlaken, Switzerland, p. 101, C.H.Schneider and A.N.Eberle, eds., Escom, Leiden, (1993)
G.B.Gurrola and L.D.Possani, Biochem. Mol. Biol. Int., 37, 527 (1995)
C.Miller, Neuron, 15, 5 (1995)