Non-Beta-Amyloid Component of Alzheimer's Disease (NAC)
Non-β-Amyloid Component of Alzheimer's Disease (NAC)
Product Code: CS9089
Longterm storage temperature: -20 C
This 35 amino acid peptide has originally been isolated from the insoluble core of Alzheimer's disease (AD) amyloid plaque. It represents the fragment (61-95) of a 140 amino acid precursor known as NACP or α-synuclein and was found to form amyloid fibrils via a nucleation-dependent polymerization mechanism. Accumulation of NAC aggregates in the synapse might be responsible for the neurodegeneration in AD and in the prion diseases.
A.Iwai et al., Biochemistry, 34, 10139 (1995)
H.Han et al., Chemistry and Biology, 2, 163 (1995)
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