C S Bio Co.

Non-β-Amyloid Component of Alzheimer's Disease (NAC)
Product Code: CS9089

Glu-Gln-Val-Thr-Asn-Val-Gly-Gly-Ala-Val-Val-Thr-Gly-Val-Thr-Ala-Val-Ala-Gln-Lys-Thr-Val-Glu-Gly-Ala-Gly-Ser-Ile-Ala-Ala-Ala-Thr-Gly-Phe-Val

C₁₄₁H₂₃₅N₃₉O₄₉
MW: 3260.58
CAS: [154040-19-4]
Longterm storage temperature: -20 C

This 35 amino acid peptide has originally been isolated from the insoluble core of Alzheimer's disease (AD) amyloid plaque. It represents the fragment (61-95) of a 140 amino acid precursor known as NACP or α-synuclein and was found to form amyloid fibrils via a nucleation-dependent polymerization mechanism. Accumulation of NAC aggregates in the synapse might be responsible for the neurodegeneration in AD and in the prion diseases.

Literature:
A.Iwai et al., Biochemistry, 34, 10139 (1995)
H.Han et al., Chemistry and Biology, 2, 163 (1995)