LL-37
Product Code: CS3651

Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser

C₂₀₅H₃₄₁N₆₁O₅₂
MW: 4493.27
CAS: [143108-26-3]
Longterm storage temperature: -20 C

LL-37 is an antimicrobial peptide with angiogenic activity. It corresponds to amino acids 134-170 of the human cathelicidin antimicrobial protein hCAP18/LL-37 and is extracellularly released from hCAP18/LL-37 by proteolytic processing. hCAP18/LL-37 is an effector of the innate immune system and is expressed in leukocytes and epithelial cells where it is upregulated in association with inflammation and injury. Recent studies demonstrated overexpression of hCAP18/LL-37 in a series of breast carcinomas. LL-37 has been suggested to stimulate epithelial cell proliferation partially through formyl peptide receptor-like 1 (FPRL1) since blocking the receptor with pertussis toxin decreased the proliferative effect of LL-37 by approximately 50 %.

Literature:
R.Koczulla et al., J. Clin. Invest., 111, 1665 (2003)
J.D.Heilborn et al., Int. J. Cancer, 114, 713 (2005)