Leiurotoxin I (LeTx I)
Product Code: CS9058

Ala-Phe-Cys-Asn-Leu-Arg-Met-Cys-Gln-Leu-Ser-Cys-Arg-Ser-Leu-Gly-Leu-Leu-Gly-Lys-Cys-Ile-Gly-Asp-Lys-Cys-Glu-Cys-Val-Lys-His-NH2 (Disulfide bonds 3-21, 8-26, 12-28)

C₁₄₂H₂₃₇N₄₅O₃₉S₇
MW: 3423.15
CAS: [142948-19-4]
Longterm storage temperature: -20 C

Scyllatoxin is a component of the venom of the Israeli scorpion Leiurus quinquestriatus hebraeus and has been reported to inhibit apamin binding to its receptor. Like apamin, it acts as a blocker of Ca2+ activated K+ channels in different cell types.

Literature:
A.Abia et al., Biochim. Biophys. Acta, 856, 403 (1986)
N.A.Castle and P.N.Strong, FEBS Lett., 209, 117 (1986)
G.G.Chicchi et al., J. Biol. Chem., 263, 10192 (1988)
J.C.Martins et al., FEBS Lett., 260, 249 (1990)
J.-M.Sabatier et al., Biochemistry, 32, 2763 (1993)