Kaliotoxin
Product Code: CS9053

Gly-Val-Glu-Ile-Asn-Val-Lys-Cys-Ser-Gly-Ser-Pro-Gln-Cys-Leu-Lys-Pro-Cys-Lys-Asp-Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys-Met-Asn-Arg-Lys-Cys-His-Cys-Thr-Pro-Lys (Disulfide bonds 8-28, 14-33, 18-35)

C₁₇₁H₂₈₃N₅₅O₄₉S₈
MW: 4149.98
CAS: [145199-73-1]
Longterm storage temperature: -20 C

Kaliotoxin, originally purified from the venom of the scorpion Androctonus mauretanicus mauretanicus, is a 38amino acid peptide showing 44% sequence homology with charybdotoxin and iberiotoxin. It acts as a specific, voltage-independent inhibitor of high conductance Ca2+ activated K+ channels present in mollusc and rabbit nerve cells.

Literature:
M.Crest et al., J. Biol. Chem., 267, 1640 (1992)
J.Van Rietschoten et al., Peptides, Chemistry, Structure and Biology, Proceedings of the 13th American Peptide Symposium, Edmonton, Alberta, Canada, p. 529, R.S.Hodges and J.A.Smith, eds., Escom, Leiden, (1994)
C.Miller, Neuron, 15, 5 (1995)