Hepcidin, human
Product Code: CS1827

Asp-Thr-His-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Gly-Cys-Cys-His-Arg-Ser-Lys-Cys-Gly-Met-Cys-Cys-Lys-Thr (Disulfide bonds 7-23, 10-13, 11-19, 14-22)

C₁₁₃H₁₇₀N₃₄O₃₁S₉
MW: 2789.40
CAS: [342790-21-0]
Longterm storage temperature: -20 C

Hepcidin-25, also referred to as LEAP-1 (liver-expressed antimicrobial peptide) has been independently discovered by two groups in human blood ultrafiltrate and urine. The peptide which is predominantly expressed in the liver, belongs to a new vertebrate family of small antimicrobial peptides that contain 8 cysteine residues and show significant antibacterial and antifungal activity. Further investigations revealed that hepicidin also acts as a key regulator of iron homeostasis.

Literature:
A.Krause et al., FEBS Lett., 480, 147 (2000)
C.H.Park et al., J. Biol. Chem., 276, 7806 (2001)
R.E.Fleming and W.S.Sly, Proc. Natl. Acad. Sci. USA, 98, 8160 (2001)
H.N.Hunter et al., J. Biol. Chem., 277, 37597 (2002)