GsMTx4
Product Code: CS8024

Gly-Cys-Leu-Glu-Phe-Trp-Trp-Lys-Cys-Asn-Pro-Asn-Asp-Asp-Lys-Cys-Cys-Arg-Pro-Lys-Leu-Lys-Cys-Ser-Lys-Leu-Phe-Lys-Leu-Cys-Asn-Phe-Ser-Phe-NH2

C₁₈₅H₂₇₃N₄₉O₄₅S₆
MW: 4095.83
CAS:
Longterm storage temperature: -20 C

GsMTx4 is a peptide that is isolated from tarantula venom (Grammostola spatulata). This protein has been shown to inhibit "stretch-sensitive" channels in cells that are opened by a stretching in the surface of the cell membrane. When these channels remain open for too long, they let an excessive amount of calcium into the blood and create health problems. Researchers at the University of Buffalo have created an ingestible version of GsMTx4 that will hopefully lead to the development of drug treatments that can be used for conditions as diverse as muscular dystrophy, cardiac arrhythmias, and urinary incontinence.

Literature:
T.M. Suchyna, J.H. Johnson, K. Hamer, J.F. Leykam, D.A. Gage, H.F. Clemo, C.M. Baumgarten and F. Sachs, J. Gen. Physiol., 115, 583 (2000)
F. Bode, F. Sachs and M.R. Franz, Nature, 409, 35 (2001)
R.E. Oswald, T.M. Suchyna, R. McFeeters, P. Gottlieb and F. Sachs, J. Biol. Chem., 277, 34443 (2002)