(Glu32)-Charybdotoxin
Product Code: CS9051

Pyr-Phe-Thr-Asn-Val-Ser-Cys-Thr-Thr-Ser-Lys-Glu-Cys-Trp-Ser-Val-Cys-Gln-Arg-Leu-His-Asn-Thr-Ser-Arg-Gly-Lys-Cys-Met-Asn-Lys-Glu-Cys-Arg-Cys-Tyr-Ser (Disulfide bonds between Cys7 and Cys²8/Cys¹³ and Cys³³/Cys¹7 and Cys³5)

C₁₇₅H₂₇₂N₅₆O₅₇S₇
Mw: 4296.85
CAS:
Longterm storage temperature: -20 C

This charybdotoxin analog selectively targeted the Ca2+-activated IKCa1 channel present in human T-lymphocytes. It has been shown that inhibitors of this channel are able to suppress the activation of human T-lymphocytes and may therefore have clinical use.

Literature:
H.Rauer et al., J. Biol. Chem., 275, 1201 (2000)