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GLP-1 (7-36)

GLP-1(7-36)
Product Code: CS3175

His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2


C149H226N40O45
MW: 3297.59
CAS: [107444-51-9]
Longterm storage temperature: -20 C


This GLP-1 fragment is secreted from the lower small intestine and shows a strong insulinotropic effect. It is presently considered as the most important incretin hormone. Its action is mediated by receptors expressed by the endocrine pancreatic B-cells. Recent interest has focused on the development of this peptide as a novel therapeutic strategy for non-insulin-dependent (type 2 ) diabetes mellitus and associated neuropathy.


Literature:
G.I.Bell et al., Nature, 304, 368 (1983)
B.Kreymann et al., Lancet, 2, 1300 (1987)
C.Orskov and J.H.Nielsen, FEBS Lett., 229, 175 (1988)
J.-P.Raufman et al., J. Biol. Chem., 267, 21432 (1992)
P.A.Martin and A.Faulkner, Comp. Biochem. Biophys., 105A, 705 (1993)
H.C.Fehmann et al., Peptides, 15, 453 (1994)
M.A.Nauck et al., Exp. Clin. Endocrinol. Diabetes, 105, 187 (1997)
T.-A.Perry and N.H.Greig, Trends Pharmacol. Sci., 24, 377 (2003)
J.J.Meier et al., Biodrugs, 17, 93 (2003)

UnitPrice per Unit
0.5 mg $120
1 mg

$180