Exendin (9-39)
Product Code: CS9042

Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2

C₁₄₉H₂₃₄N₄₀O₄₇S
MW: 3369.75
CAS: [133514-43-9]
Longterm storage temperature: -20 C

Exendin (9-39) is a potent glucagon-like peptide 1 (GLP-1) receptor antagonist. It has also been described as an antagonist of the putative exendin receptor. This peptide blocks the stimulatory action of GLP-1 (7- 36) amide (H- 6795) and of exendin-4 (H- 8730) on cAMP production in pancreatic acini. - Moreover, exendin (9-39) was shown to be safely used to abolish the incretin effect of GLP-1 without interfering with the control of insulin secretion by circulating nutrients.

Literature:
J.Eng et al., J. Biol. Chem., 267, 7402 (1992)
J.-P.Raufman et al., J. Biol. Chem., 267, 21432 (1992)
H.C.Fehmann et al., Peptides, 15, 453 (1994)
J.Cancelas et al., Horm. Metab. Res., 34, 13 (2002)