(Dap22)-Stichodactyla helianthus Neurotoxin (ShK)
Product Code: CS9048

Arg-Ser-Cys-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys-Thr-Ala-Phe-Gln-Cys-Lys-His-Ser-Met-Dap-Tyr-Arg-Leu-Ser-Phe-Cys-Arg-Lys-Thr-Cys-Gly-Thr-Cys (Disulfide bonds between Cys³ and Cys³5/Cys¹² and Cys²8/Cys¹7 and Cys³²)

C₁₆₆H₂₆₈N₅₄O₄₈S₇
Mw: 4012.74
CAS:
Longterm storage temperature: -20 C

This derivative of H-2358 is a very potent Kv 1.3 channel specific immunosuppressive peptide (Kd = 20 pM). It inhibited T cell proliferation.

Literature:
K.Kalman et al., J. Biol. Chem., 273, 32697 (1998)
C.Beeton et al., Proc. Natl. Acad. Sci. USA, 98, 13942 (2001)