β-Amyloid (1-46)
Product Code: CS9164

H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-Thr-Val-Ile-Val-OH

C₂₂₃H₃₄₇N₅₉O₆₅S
MW:4926.63
CAS: [285554-31-6]
Longterm storage temperature: -20 C

Precursor of the secreted amyloid-β-protein 1-40 and 1-42. The identification of amyloid-β-protein 1-46 led to the identification of a zeta-cleavage site between the known γ- and ε-cleavage sites within the transmembrane domain of amyloid-β precursor protein (APP).

Literature:
G.Zhao et al., J. Biol. Chem., 279, 50647 (2004)
G.Zhao et al., J. Biol. Chem., 280, 37689 (2005)
Y.Qi-Takahara et al., J. Neurosci., 25, 436 (2005)