β-Amyloid (1-42)
Product Code: CS1882

H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH
(Hydrochloride salt)

C₂₀₃H₃₁₁N₅₅O₆₀S
MW:4514.10
CAS: [107761-42-2]
Longterm storage temperature: -20 C

This 42-residue fragment of amyloid β-protein has been found to be a major constituent of the senile plaques formed in the brains of patients with Alzheimer's disease and late Down's syndrome. Aβ 1-42 readily forms neurotoxic oligomers at physiological pH. The peptide has been used to detect amyloid β-protein multimers in the cerebrospinal fluid of Alzheimer's disease patients through fluorescence correlation spectroscopy.

Literature:
J.Kang et al., Nature, 325, 733 (1987)
D.Goldgaber et al., Science, 235, 877 (1987)
J.Murrell et al., Science, 254, 97 (1991)
C.J.Pike et al., Neuroscience, 63, 517 (1994)
M.Pitschke et al., Nat. Med., 4, 832 (1998)
G.Bitan et al., Proc. Natl. Acad. Sci. USA, 100, 330 (2003)
D.A.Butterfield and D.Boyd-Kimball, Biochim. Biophys. Acta, 1703, 149 (2005)
S.Gandy, J. Clin. Invest., 115, 1121 (2007)
D.M.Walsh and D.J.Selkoe, J. Neurochem., 101, 1172 (2007)
A.Jan et al., Nat. Protoc., 5, 1186 (2010)