β-Amyloid (1-40)
Product Code: CS9019

H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH
Trifluoroacetate salt

C₁₉₄H₂₉₅N₅₃O₅₈S
MW:4329.86
CAS: [131438-79-4]
Longterm storage temperature: -20 C

Amyloid β-protein (1-40) showed both neurotrophic and neurotoxic effects in dependence on the neuronal age and the concentration of the β-protein. Aβ 1-40 has been used as well as Aβ 1-42 to detect amyloid β-protein multimers in the cerebrospinal fluid of Alzheimer's disease patients. H-2972, the inverted Aβ 1-40 sequence, can be used as inactive control in experiments employing H-1194. For detailed descriptions of the preparation of wild-type and mutant Aβ 1-40 monomers and protofibrils please see the paper of Jan, Hartley, and Lashuel.

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A.Jan et al., Nat. Protoc., 5, 1186 (2010)