C S Bio Co.

β-Amyloid/A4 Protein Precursor770 (740-770)
Synonym: APP770 (740-770), C31
Product Code: CS9191

H-Ala-Ala-Val-Thr-Pro-Glu-Glu-Arg-His-Leu-Ser-Lys-Met-Gln-Gln-Asn-Gly-Tyr-Glu-Asn-Pro-Thr-Tyr-Lys-Phe-Phe-Glu-Gln-Met-Gln-Asn-OH
(Trifluoroacetate salt)

C₁₆₂H₂₄₃N₄₅O₅₂S₂
MW:3717.12
CAS:
Longterm storage temperature: -20 C

Amyloid β/A4 Protein Precursor770 (740-770) corresponds to a C-terminal amyloid precursor protein (APP) fragment known as C31. This fragment is intracellularly generated by proteolytic cleavage of APP by caspases-8 and -9. C31 had a proapoptotic and a cytotoxic effect on neuronal cells and was shown to be present in brains of Alzheimer's disease (AD) patients. In cultured cells caspase cleavage of APP was induced by amyloid β-protein and the subsequent generation of C31 contributed to the apoptotic cell death associated with amyloid β-protein. Amyloid precursor binding protein BP1 (APP-BP1) a cell cycle protein which is increased in AD brain was demonstrated to bind to the C31 region of APP and to mediate APP-induced apoptosis.

Literature:
D.C.Lu et al., Nat. Med., 6, 397 (2000)
C.Dumanchin-Njock et al., J. Neurochem., 78, 1153 (2001)
V.Galvan et al., J. Neurochem., 82, 283 (2002)
D.C.Lu et al., J. Neurochem., 87, 733 (2003)
Y.Chen et al., J. Cell Biol., 163, 27 (2003)