Apamin
Product Code: CS9059

Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2 (Disulfide bonds 1-11, 3-15)

C₇₉H₁₃₁N₃₁O₂₄S₄
MW: 2027.34
CAS: [24345-16-2]
Longterm storage temperature: -20 C

Apamin, which has been isolated from bee venom, is the smallest neurotoxic polypeptide known. It is the only polypeptide neurotoxin that passes the blood-brain barrier. It has several features in common with the snake and scorpion neurotoxins: like these, apamin is a low-molecular-weight basic peptide, and the molecule is crosslinked by disulfide bridges.

Literature:
J.Van Rietschoten et al., Eur. J. Biochem., 56, 35 (1975)
M.Hugues et al., Proc. Natl. Acad. Sci. USA, 79, 1308 (1982)