Amylin, human
Synonym:IAPP (human), Islet Amyloid Polypeptide (human)
Product Code: CS2906

H-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Ala-Ile-Leu-Ser-Ser-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2
(Disulfide bond)

C₁₆₅H₂₆₁N₅₁O₅₅S₂
MW:3903.33
CAS: [122384-88-7]
Longterm storage temperature: -20 C

The amyloidogenic peptide hormone amylin (or Islet Amyloid Polypeptide, IAPP) has been isolated from the amyloid-rich pancreases of diabetic patients. IAPP forms fibrillar peptide deposits in the pancreatic islets of Langerhans, which may be related to death of the insulin-producing islet β-cells in type 2 diabetes mellitus.

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G.T.Westermark and P.Westermark, Exp. Diabetes Res., ID528354 (2008)
L.Khemtémourian et al., Exp. Diabetes REs., ID421287 (2008)