Amylin (8-37), rat
Product Code: CS9043

Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-Arg-Ser-Ser-Asn-Asn-Leu-Gly-Pro-Val-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2

C₁₄₀H₂₂₇N₄₃O₄₃
MW: 3200.54
CAS: [138398-61-5]
Longterm storage temperature: -20 C

The effect of amylin (8-37) (rat), an amylin receptor antagonist, on the ANP release was attenuated in streptozotocin-treated rats.
This is a truncated peptide of native rat amylin. In-vivo and in-vitro studies suggest that it acts as a specific amylin antagonist. In isolated soleus muscle, it blocks amylin-induced inhibition of glycogen synthesis but has no effect in the absence of amylin. Amylin (8-37) increases whole body and muscle insulin sensitivity and consistently reduces basal insulin levels in normal and hGH-induced insulin-resistant rats. It also elicits a significant alteration of in-vivo lipid metabolism.

Literature:
R.O.Deems et al., Biochem. Biophys. Res. Commun., 181, 116 (1991)
F.L.Piao et al., Regul. Peptides,
Hettiarachchi, M. et al. Am. J. Physiol. Endocrinol. Metab. 273, E859 (1997)