(Ala22)-Stichodactyla helianthus Neurotoxin (ShK)
Product Code: CS3641

Arg-Ser-Cys-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys-Thr-Ala-Phe-Gln-Cys-Lys-His-Ser-Met-Ala-Tyr-Arg-Leu-Ser-Phe-Cys-Arg-Lys-Thr-Cys-Gly-Thr-Cys

C₁₆₆H₂₆₇N₅₃O₄₈S₇
Mw: 3997.73
CAS:
Longterm storage temperature: -20 C

This peptide substitutes the critical Lys22 with an Ala in the peptide sequence for ShK toxin. Substitution abolishes rat brain Kv1.2 binding but does not affect lymphocyte Kv1.3 binding.

Literature:
M.W.Pennington et al., Biochem. Biophys. Res. Commun., 219, 696 (1996)
J.E.Tudor et al., Nat. Struct. Biol., 3, 317 (1996)
M.W.Pennington et al., Peptides: Chemistry, Structure and Biology, p. 192, P.T.P.Kaumaya and R.S.Hodges, eds., Mayflower Scientific Ltd., (1996)
M.W.Pennington et al., A Guidebook to Protein Toxins and their Use in Cell Biology, p. 159, C.Montecucco and R.Rappuoli, eds., Oxford University Press, (1997)