α Defensin 6
Product Code: CS9138

Ala-Phe-Thr-Cys-His-Cys-Arg-Arg-Ser-Cys- Tyr-Ser-Thr-Glu-Tyr-Ser-Tyr-Gly-Thr-Cys- Thr-Val-Met-Gly-Ile-Asn-His-Arg-Phe-Cys- Cys-Leu [Disulfide bonds between Cys⁴ and Cys³¹/Cys⁶ and Cys²⁰/Cys¹⁰ and Cys³⁰)]
Trifluoroacetate salt

C₁₅₆H₂₂₈N₄₆O₄₆S₇
MW:3708.24
CAS:
Longterm storage temperature: -20 C

Cysteine-rich cationic peptide with antiviral activity against HSV infection and a role in N. gonorrhoeae-mediated HIV enhancement. In contrast to the other members of the ƒ-defensin family it shows very low antimicrobial activity against Gram-negative and Gram-positive bacteria. As a biomarker of colon adenocarcinoma it may have utility in colon cancer screening and diagnosis.

Literature:
Z.Wu et al., J. Pept. Res., 64, 118 (2004)
M.J.Nam et al., J. Biol. Chem., 280, 8260 (2005)
E.Hazrati et al., J. Immunol., 177, 8658 (2006)
A.Szyk et al., Protein Sci., 15, 2749 (2006)
M.E.Klotman et al., J. Immunol., 180, 6176 (2008)